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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - BRD7-IN-1

BRD7-IN-1

CAS No. 2448414-48-8

BRD7-IN-1( —— )

Catalog No. M33545 CAS No. 2448414-48-8

BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 240 In Stock
2MG 140 In Stock
5MG 235 In Stock
10MG 353 In Stock
25MG 635 In Stock
50MG 923 In Stock
100MG 1283 In Stock
200MG 1748 In Stock
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Biological Information

  • Product Name
    BRD7-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively .
  • Description
    BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Epigenetic Reader Domain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2448414-48-8
  • Formula Weight
    467.39
  • Molecular Formula
    C22H28Cl2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 100 mg/mL (213.95 mM; Ultrasonic)DMSO : 30 mg/mL (64.19 mM; Ultrasonic )
  • SMILES
    Cl.Cl.COc1cc(cc(OC)c1CN1CCNCC1)-c1cn(C)c(=O)c2cnccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62?
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