Biotin-PEG4-Picolyl azide

Research use only, not for human use.

Biotin-PEG4-Picolyl azide is a PROTAC linker belonging to the class of PEGs that can be used to synthesize PROTAC molecules.

Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Others

Other Targets

PROTACs

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2222687-71-8

622.74

C27H42N8O7S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (200.73 mM; Ultrasonic )

C(CCCC(NCCOCCOCCOCCOCCC(NC=1C=CC(CN=[N+]=[N-])=NC1)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]

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(-20℃)

With Ice Pack

≥ 2 years