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ZXH-3-26 B
CAS No. 2243076-67-5
ZXH-3-26 B( —— )
Catalog No. M33536 CAS No. 2243076-67-5
ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 350 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZXH-3-26 B
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NoteResearch use only, not for human use.
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Brief DescriptionZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.
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DescriptionZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPROTACs
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Research Area——
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Indication——
Chemical Information
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CAS Number2243076-67-5
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Formula Weight785.27
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Molecular FormulaC38H37ClN8O7S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (254.69 mM; Ultrasonic )
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SMILESCC=1C2=C(N3C([C@H](CC(OC)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C(NCCCCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.?
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