TCO-NHS ester( —— )

Catalog No. M33512 CAS No. 1191901-33-3

TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

TCO-NHS ester
Note

Research use only, not for human use.
Brief Description

TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.
Description

TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

——
Synonyms

——
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC Linker
Research Area

——
Indication

——

Chemical Information

CAS Number

1191901-33-3
Formula Weight

267.28
Molecular Formula

C13H17NO5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (374.14 mM; Ultrasonic )
SMILES

O=C(OC1CCCC=CCC1)ON1C(=O)CCC1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?

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