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R121919
CAS No. 195055-03-9
R121919( —— )
Catalog No. M33474 CAS No. 195055-03-9
R121919 (NBI30775) is a potent small molecule antagonist of the adrenocorticotropic hormone-releasing factor receptor 1 (CRF1), demonstrating antidepressant and anxiolytic activity, and inhibiting the CRF1 receptor, CRF2 receptor, and CRF-binding proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 282 | In Stock |
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| 50MG | 454 | In Stock |
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| 100MG | 728 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameR121919
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NoteResearch use only, not for human use.
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Brief DescriptionR121919 (NBI30775) is a potent small molecule antagonist of the adrenocorticotropic hormone-releasing factor receptor 1 (CRF1), demonstrating antidepressant and anxiolytic activity, and inhibiting the CRF1 receptor, CRF2 receptor, and CRF-binding proteins.
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DescriptionR121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number195055-03-9
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Formula Weight380.53
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Molecular FormulaC22H32N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 100 mg/mL (262.79 mM; Ultrasonic) DMSO : 6.2 mg/mL (16.29 mM; Ultrasonic )
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SMILESCCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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5-Methylcytosine
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. In animals the DNA methylation of cytosine to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In plants the methylated sequence is CpNpGp where N can be any base. 5-Methylcytosine is an epigenetic modification formed by the action of DNA methyltransferases.
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MC1742
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).
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Taraxeryl acetate
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol.
