Hematein

Research use only, not for human use.

Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells.

Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells.

Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells. Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells. Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation. Cell Viability Assay Cell Line:A427 (HTB-53) cell line Concentration:10-100 μM Incubation Time:14 days Result:Inhibited cells growth.Apoptosis Analysis Cell Line:A427 (HTB-53) cell line Concentration: 50 and 100 μM Incubation Time:48 hours Result:Induced apoptosis in A427 lung cancer cells.Western Blot Analysis Cell Line:A427 (HTB-53) cell line Concentration:50 and 100 μM Incubation Time:48 hours Result:Inhibited CK2-specific Akt phosphorylation.

Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts. Animal Model:Female athymic BALB/c nude mice (6-week-old) Dosage:50 mg/kg Administration:Intraperitoneal injections; twice a week for 6 weeks Result:Inhibited tumor growth in A427 lung cancer cell xenografts.

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Wnt/Notch/Hedgehog

Wnt/beta/catenin

Wnt/beta-catenin | Akt

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475-25-2

300.26

C16H12O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (333.04 mM; Ultrasonic )

OC1=CC2=C3c4ccc(O)c(O)c4OCC3(O)CC2=CC1=O

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(-20℃)

With Ice Pack

≥ 2 years