Cart
sales@molnova.com
GLP-1R Antagonist 1
CAS No. 488097-06-9
GLP-1R Antagonist 1( —— )
Catalog No. M33369 CAS No. 488097-06-9
GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | Get Quote |
|
| 2MG | 58 | Get Quote |
|
| 5MG | 85 | Get Quote |
|
| 10MG | 140 | Get Quote |
|
| 25MG | 264 | Get Quote |
|
| 50MG | 419 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGLP-1R Antagonist 1
-
NoteResearch use only, not for human use.
-
Brief DescriptionGLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).
-
DescriptionGLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetGlucagon Receptor
-
RecptorGlucagon Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number488097-06-9
-
Formula Weight440.73
-
Molecular FormulaC16H11ClF6N4O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (226.90 mM; Ultrasonic )
-
SMILESCn1c2NC(=NC(c2c(=O)n(C)c1=O)(C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.?
molnova catalog
related products
-
CCG-143140
CCG-143140 is a GLP-1 receptor inverse agonists.
-
Tirzepatide
Tirzepatide (TZP), a novel dual GIP and GLP-1 receptor agonist (RA).
-
NNC 92-1687
NNC 92-1687 is a selective glucagon receptor antagonist that can be used to study type 2 diabetes.
