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Fedovapagon
CAS No. 347887-36-9
Fedovapagon( —— )
Catalog No. M33357 CAS No. 347887-36-9
Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | Get Quote |
|
| 10MG | 170 | Get Quote |
|
| 25MG | 361 | Get Quote |
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| 50MG | 634 | Get Quote |
|
| 100MG | 876 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameFedovapagon
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NoteResearch use only, not for human use.
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Brief DescriptionFedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish.
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DescriptionFedovapagon (VA106483) is a selective and orally active vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM. Fedovapagon can be used in the research of nocturia.
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In Vitro——
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In VivoFedovapagon (1 mg/kg, oral administration) inhibits urine output with 81% inhibition rate in rats.Animal Model:Brattleboro rats Dosage:1 mg/kg, 3 mg/kg Administration:Oral administration Result:Reduced urine volume with almost full inhibition of urine output for 2 h.Returned the urine to normal levels 5 h after dosing.
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Synonyms——
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PathwayGPCR/G Protein
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TargetVasopressin Receptor
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RecptorVasopressin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number347887-36-9
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Formula Weight462.58
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Molecular FormulaC27H34N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 125 mg/mL (270.22 mM )
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SMILES[H][C@]1(CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1CCCCc2ccccc12)C(=O)N(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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TASP0390325
TASP0390325 is an orally active and high affinity arginine pressin receptor 1B (V1B receptor) antagonist that shows antidepressant and anxiolytic activity in animal studies and blocks V1B receptors in the anterior pituitary gland in vivo.
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(d(CH2)51,Tyr(Me)2,A...
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
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Mozavaptan
Mozavaptan (OPC-31260) is a potent, selective nonpeptide vasopressin V2 receptor antagonist with IC50 of 14 nM; 100-fold less potent for VP1 (IC50=1.2 uM).
