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Home - Products - GPCR/G Protein - CRF Receptor - CP 316311

CP 316311

CAS No. 175139-41-0

CP 316311( —— )

Catalog No. M33325 CAS No. 175139-41-0

CP 316311 is a specific CRF1 receptor antagonist with potential antidepressant activity and may be used in the study of depression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CP 316311
  • Note
    Research use only, not for human use.
  • Brief Description
    CP 316311 is a specific CRF1 receptor antagonist with potential antidepressant activity and may be used in the study of depression.
  • Description
    CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.
  • In Vitro
    CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively.
  • In Vivo
    CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic?pituitary?adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    CRF Receptor
  • Recptor
    CRFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    175139-41-0
  • Formula Weight
    327.46
  • Molecular Formula
    C21H29NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N=1C(OC=2C(=CC(=CC2C)C)C)=C(C(OC(CC)CC)=CC1C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen YL, et al. Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists. J Med Chem. 2008 Mar 13;51(5):1377-84.?
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