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CCT020312

CAS No. 324759-76-4

CCT020312( —— )

Catalog No. M33308 CAS No. 324759-76-4

CCT020312 (0-9 μM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 188 In Stock
5MG 136 In Stock
10MG 240 In Stock
25MG 408 In Stock
50MG 591 In Stock
100MG 821 In Stock
200MG Get Quote In Stock
500MG 1702 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    CCT020312
  • Note
    Research use only, not for human use.
  • Brief Description
    CCT020312 (0-9 μM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB signaling with linear response values between 1.8 and 6.1 μM.
  • Description
    CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
  • In Vitro
    ——
  • In Vivo
    Animal Model:9-week-old P301S tau transgenic mice Dosage:2 mg/kg Administration:Intraperitoneal injection; once daily for 6 weeks Result:P301S transgenic mice treated with CCT020312 performed significantly better in Morris water maze.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    PERK
  • Recptor
    PERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    324759-76-4
  • Formula Weight
    650.4
  • Molecular Formula
    C31H30Br2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (153.75 mM; Ultrasonic )
  • SMILES
    CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568.?
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