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Barbadin

CAS No. 356568-70-2

Barbadin( —— )

Catalog No. M33283 CAS No. 356568-70-2

Barbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 135 In Stock
5MG 123 In Stock
10MG 183 In Stock
25MG 310 In Stock
50MG 451 In Stock
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Biological Information

  • Product Name
    Barbadin
  • Note
    Research use only, not for human use.
  • Brief Description
    Barbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2.
  • Description
    Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis.
  • In Vitro
    Barbadin (4 h) treatment reduces cell viability and induces apoptosis.?Barbadin (2 h) treatment arrests breast cancer cells in G0/G1 phase.Apoptosis Analysis Cell Line:MDA MB-231 cells Concentration:Incubation Time:4 hoursResult:Exhibited morphological characteristics of apoptosis including shrinkage, rounding and detachment, the percent of cell viability was reduced to 69.1% and apoptosis was developed in 29.9% of cells starved with EBSS (Earle’s balanced salt solution).Cell Cycle AnalysisCell Line:MDA MB-231 cells Concentration:Incubation Time:2 hours Result:Arrested 63.7% of cells in G0/G1 phase.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Arrestin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    356568-70-2
  • Formula Weight
    333.41
  • Molecular Formula
    C19H15N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (149.97 mM; Ultrasonic )
  • SMILES
    Nn1cnc2scc(-c3ccc(Cc4ccccc4)cc3)c2c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.?
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