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Tiludronate disodium
CAS No. 149845-07-8
Tiludronate disodium( —— )
Catalog No. M33150 CAS No. 149845-07-8
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 111 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 276 | In Stock |
|
| 100MG | 410 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 826 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTiludronate disodium
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NoteResearch use only, not for human use.
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Brief DescriptionTiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties.
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DescriptionTiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
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In VitroThe ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible.
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In VivoTiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorATPase
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Research Area——
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Indication——
Chemical Information
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CAS Number149845-07-8
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Formula Weight362.57
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Molecular FormulaC7H7ClNa2O6P2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 62.5 mg/mL (172.38 mM; Ultrasonic)
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SMILES[Na+].[Na+].OP([O-])(=O)C(Sc1ccc(Cl)cc1)P(O)([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989 Dec 23-30;2(8678-8679):1469-71.?
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