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SIRT5 inhibitor 1

CAS No. 2166487-21-2

SIRT5 inhibitor 1( —— )

Catalog No. M33124 CAS No. 2166487-21-2

SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM) and is associated with aging-related diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 466 In Stock
2MG 207 In Stock
5MG 353 In Stock
10MG 530 In Stock
25MG 934 In Stock
50MG 1330 In Stock
100MG 1786 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    SIRT5 inhibitor 1
  • Note
    Research use only, not for human use.
  • Brief Description
    SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM) and is associated with aging-related diseases.
  • Description
    SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
  • In Vitro
    SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2166487-21-2
  • Formula Weight
    674.81
  • Molecular Formula
    C31H39FN6O6S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (185.24 mM; Ultrasonic )
  • SMILES
    OC(=O)CCNC(=S)NCCCC[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841.?
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