SIRT5 inhibitor 1( —— )

Catalog No. M33124 CAS No. 2166487-21-2

SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM) and is associated with aging-related diseases.

Purity : >98% (HPLC)

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HNMR

HPLC

MSDS

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Biological Information

Product Name

SIRT5 inhibitor 1
Note

Research use only, not for human use.
Brief Description

SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM) and is associated with aging-related diseases.
Description

SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
In Vitro

SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1.
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

Chemical Information

CAS Number

2166487-21-2
Formula Weight

674.81
Molecular Formula

C31H39FN6O6S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (185.24 mM; Ultrasonic )
SMILES

OC(=O)CCNC(=S)NCCCC[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841.?

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