RO5263397( —— )

Catalog No. M33107 CAS No. 1357266-05-7

RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	75	In Stock
5MG	68	In Stock
10MG	122	In Stock
25MG	274	In Stock
50MG	400	In Stock
100MG	578	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

RO5263397
Note

Research use only, not for human use.
Brief Description

RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.
Description

RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect.
In Vitro

——
In Vivo

Animal Model:Adult 4-5-month-old male WT littermates (C57BL/6 background) Dosage:0.1, 0.3, 1?mg/kg Administration:p.o.; dosing at the mid-light phase (ZT6)?Result:Increased wake time at 0.3 and 1?mg/kg
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1357266-05-7
Formula Weight

194.21
Molecular Formula

C10H11FN2O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 260 mg/mL (1338.76 mM; Ultrasonic )
SMILES

Cc1c(F)cccc1[C@H]1COC(N)=N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett.?2015 Dec 30;7(2):192-7.?

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