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PPTN
CAS No. 1160271-30-6
PPTN( —— )
Catalog No. M33073 CAS No. 1160271-30-6
PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 178 | Get Quote |
|
| 5MG | 256 | Get Quote |
|
| 10MG | 375 | Get Quote |
|
| 25MG | 545 | Get Quote |
|
| 50MG | 767 | Get Quote |
|
| 100MG | 1008 | Get Quote |
|
| 500MG | 2034 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePPTN
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NoteResearch use only, not for human use.
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Brief DescriptionPPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.
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DescriptionPPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity.
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In VitroPPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM.PPTN (10 μM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetP2Y Receptor
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RecptorP2Y Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1160271-30-6
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Formula Weight475.5
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Molecular FormulaC29H24F3NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(O)(=O)C=1C=C(C2=C(C=C(C=C2)C3=CC=C(C(F)(F)F)C=C3)C1)C4=CC=C(C=C4)C5CCNCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9.?
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