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CSRM617 hydrochloride
CAS No. 1353749-74-2
CSRM617 hydrochloride( —— )
Catalog No. M32871 CAS No. 1353749-74-2
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 μM in SPR assays, directly binding to the OC2-HOX domain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 155 | In Stock |
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| 50MG | 225 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCSRM617 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 μM in SPR assays, directly binding to the OC2-HOX domain.
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DescriptionCSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model
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In VitroCSRM617 (0.01-100 μM; 48 hours) hydrochloride inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells.CSRM617 (10-20 μM; 48 hours) hydrochloride induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion.CSRM617 (20 μM; 72 hours) hydrochloride induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP.
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In VivoCSRM617 (50 mg/kg; p.o.; daily, for 20 d) inhibits tumor growth in SCID mice with 22Rv1 xenograft.Animal Model:SCID mice with 22Rv1 xenograft Dosage:50 mg/kg Administration:Oral administration; daily, for 20 days Result:Elicited a significant reduction in the onset and growth of diffuse metastases.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Androgen Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1353749-74-2
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Formula Weight291.69
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Molecular FormulaC10H14ClN3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (428.54 mM; Ultrasonic )
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SMILESCl.NC(CO)C(=O)N\N=C\c1ccc(O)c(O)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rotinen M, et, al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898. ?
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