CGP 20712 A( —— )

Catalog No. M32841 CAS No. 105737-62-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

CGP 20712 A
Note

Research use only, not for human use.
Brief Description

CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
Description

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.
In Vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.
In Vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.
Synonyms

——
Pathway

GPCR/G Protein
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

——
Indication

——

CAS Number

105737-62-0
Formula Weight

590.57
Molecular Formula

C24H29F3N4O8S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (169.33 mM; Ultrasonic )
SMILES

O=C(N)C1=CC(OCCNCC(O)COC=2C=CC(=CC2)C3=NC(=CN3C)C(F)(F)F)=CC=C1O.O=S(=O)(O)C
Chemical Name

——

1. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9.?

Calculator

molnova catalog