BRCA1-IN-2( —— )

Catalog No. M32817 CAS No. 1622262-55-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BRCA1-IN-2
Note

Research use only, not for human use.
Brief Description

BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.
Description

BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

1622262-55-8
Formula Weight

544.54
Molecular Formula

C26H33N4O7P
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (183.64 mM; Ultrasonic )
SMILES

C(CC(N[C@H](C(NCC(NCCCCC1=CC=CC=C1)=O)=O)COP(=O)(O)O)=O)C=2C=3C(NC2)=CC=CC3
Chemical Name

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1. Na Z, et al. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays. Methods Mol Biol. 2017;1518:139-156.?

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