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Bisindolylmaleimide X hydrochloride

CAS No. 145317-11-9

Bisindolylmaleimide X hydrochloride( —— )

Catalog No. M32811 CAS No. 145317-11-9

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor and a CDK2 antagonist with an IC50 of 200 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 136 In Stock
5MG 123 In Stock
10MG 215 In Stock
25MG 411 In Stock
50MG 635 In Stock
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Biological Information

  • Product Name
    Bisindolylmaleimide X hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor and a CDK2 antagonist with an IC50 of 200 nM.
  • Description
    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM.
  • In Vitro
    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC | CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    145317-11-9
  • Formula Weight
    460.96
  • Molecular Formula
    C26H25ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (45.19 mM; Ultrasonic ) H2O : < 0.1 mg/mL (insoluble)
  • SMILES
    Cl.Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCn3c3ccccc23)c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brehmer D, et al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.?
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