BI-9321 trihydrochloride( —— )

Catalog No. M32809 CAS No. 2387510-87-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BI-9321 trihydrochloride
Note

Research use only, not for human use.
Brief Description

BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
Description

BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of theNSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Histone Methyltransferase
Research Area

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Indication

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CAS Number

2387510-87-2
Formula Weight

469.81
Molecular Formula

C22H24Cl3FN4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (532.13 mM; Ultrasonic ) H2O : 25 mg/mL (53.21 mM; Ultrasonic)
SMILES

Cl.Cl.Cl.Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccnc2cc(F)ccc12
Chemical Name

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1. B?ttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.?

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