Cart
sales@molnova.com
BI-9321 trihydrochloride
CAS No. 2387510-87-2
BI-9321 trihydrochloride( —— )
Catalog No. M32809 CAS No. 2387510-87-2
BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 111 | In Stock |
|
| 5MG | 101 | In Stock |
|
| 10MG | 180 | In Stock |
|
| 25MG | 353 | In Stock |
|
| 50MG | 585 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBI-9321 trihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionBI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
-
DescriptionBI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of theNSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHistone Methyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2387510-87-2
-
Formula Weight469.81
-
Molecular FormulaC22H24Cl3FN4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (532.13 mM; Ultrasonic ) H2O : 25 mg/mL (53.21 mM; Ultrasonic)
-
SMILESCl.Cl.Cl.Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccnc2cc(F)ccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Toddalolactone 3-O-m...
Toddalolactone 3′-O-methyl ether is a natural product for research related to life sciences.
-
Strontium chloride
Strontium chloride is an agonist of Calcium sensing receptor (CaSR) and directly affects C-type nerve fibers.
-
PKC ζ pseudosubstrat...
Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.
