β-NF-JQ1( —— )

Catalog No. M32806 CAS No. 2380000-55-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

β-NF-JQ1
Note

Research use only, not for human use.
Brief Description

β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.
Description

β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PROTACs
Research Area

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Indication

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CAS Number

2380000-55-3
Formula Weight

816.36
Molecular Formula

C45H42ClN5O6S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (122.49 mM; Ultrasonic )
SMILES

CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC4=CC=C(C=C4)C=5OC=6C(C(=O)C5)=C7C(=CC6)C=CC=C7)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C
Chemical Name

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1. Ohoka N, et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS Chem Biol. 2019 Oct 16.?

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