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8-M-PDOT
CAS No. 134865-70-6
8-M-PDOT( —— )
Catalog No. M32761 CAS No. 134865-70-6
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
|
| 5MG | 61 | In Stock |
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| 10MG | 112 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name8-M-PDOT
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NoteResearch use only, not for human use.
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Brief Description8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
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Description8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.
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In Vitro——
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In Vivo8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect.Animal Model:Male Wistar rats (280-320 g) with Rotenone Dosage:10 μg/μL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result:Increased percentage of time spent in the open arms and in the number of open arms entries.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number134865-70-6
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Formula Weight233.31
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Molecular FormulaC14H19NO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (428.61 mM; Ultrasonic )
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SMILESCCC(=O)NC1CCc2cccc(OC)c2C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86.?
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