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erythro-Austrobailignan-6
CAS No. 114127-24-1
erythro-Austrobailignan-6( —— )
Catalog No. M32474 CAS No. 114127-24-1
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | In Stock |
|
| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Nameerythro-Austrobailignan-6
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NoteResearch use only, not for human use.
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Brief Descriptionerythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK.
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Descriptionerythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .
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In VitroCell Viability Assay Cell Line:4T-1 and MCF-7 cells Concentration:0-30 μM Incubation Time:24 or 48 h Result:Dose dependently inhibited cell proliferation.Western Blot Analysis Cell Line:4T-1 and MCF-7 cells Concentration:100 μM Incubation Time:30, 60 or 120 min Result:Increased phosphorylation of p38 and JNK.Activated caspase-3 and inhibited CDK-4 and cyclin D1.
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In VivoAnimal Model:4T-1 tumor bearing mice Dosage:20 mg/kg/day Administration:Food intake Result:Inhibited tumor growth by 40.8%;Down-regulated CDK-4, cyclin D1, HER2 and integrin β3; Up-regulated cleaved caspase-3 in tumor.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number114127-24-1
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Formula Weight328.4
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Molecular FormulaC20H24O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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