Azadirachtin B

Research use only, not for human use.

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica and it is active against the Epstein-Barr virus early antigen (EBV-EA).

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica and it is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.

Azadirachtin B (1 pM-100 μM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells. Azadirachtin B increases expression of RunX-2 ～2.5 fold at 10 nM concentration, ALP expression ～2.8 fold at 10 nM and 100 pM concentration and OCN expression ～2.5 folds at 10 nM as compared with control.Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 μg/g body weight, in 92 h.Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA). Cell Proliferation Assay Cell Line:Osteoblast cells Concentration:1 pM, 100 pM, 10 nM, 1 μM, 100 μM Incubation Time:48 hours Result:Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.

On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity.

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Others

Other Targets

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106500-25-8

662.7

C33H42O14

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (75.45 mM)

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(-20℃)

With Ice Pack

≥ 2 years