Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression.

Isocarlinoside, L-malic acid, trans-aconitic acid, (+)-isocitric acid , 5-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, 2"-O-rhamnosylisoorientin, and 7-O-(2"-O-glucuronosyl)glucuronosyltricin showed high antifeeding activity against brown planthopper only when they were combined.

Isorutarin is a natural product that can be isolated from the seeds of Apium graueolens.