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Isocucurbitacin D
CAS No. 68422-20-8
Isocucurbitacin D( —— )
Catalog No. M32270 CAS No. 68422-20-8
Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 551 | In Stock |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameIsocucurbitacin D
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NoteResearch use only, not for human use.
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Brief DescriptionIsocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin.
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DescriptionIsocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. Isocucurbitacin D exhibited the highest activities of improved the LDL uptake rate.Isocucurbitacin D dose-dependently increased LDLR protein levels and decreased PCSK9 protein levels.
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In VitroIsocucurbitacin D inhibits tumor cell growth with ED50s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively. Cell Proliferation Assay Cell Line:MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells Concentration:0-100 μM Incubation Time:48 h Result:Inhibited cell proliferation with IC50s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number68422-20-8
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Formula Weight516.7
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Molecular FormulaC30H44O7
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Purity>98% (HPLC)
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SolubilityDMSO, Pyridine, Methanol, Ethanol, etc.
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.J Nat Prod., 2020 Dec 24;83(12):3536-3544.
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