Cinnamtannin A2

Research use only, not for human use.

Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone.

Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti-diabetic, and nephroprotective effects.

Cinnamtannin A2 (0.125-2.0 μg/mL) inhibits LDL oxidation induced by copper ions or MeO-AMVN.

Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway.Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice. Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice. Animal Model:Male Sprague-Dawley rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys Dosage:10 mg/kg Administration:I.p. for 30 days Result:Ameliorated the altered level of creatinine, blood urea nitrogen, Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea.Reduced the oxidative stress level.Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue.Reduced the tubular injury score in the kidney tissue.

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Others

Other Targets

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86631-38-1

1155.1

C60H50O24

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years