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Homatropine
CAS No. 87-00-3
Homatropine( —— )
Catalog No. M32070 CAS No. 87-00-3
The herbs of Atropa belladonna L.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHomatropine
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NoteResearch use only, not for human use.
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Brief DescriptionThe herbs of Atropa belladonna L.
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DescriptionThe herbs of Atropa belladonna L.
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In VitroHomatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs.Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.
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In VivoHomatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats. Animal Model:Male albino rats Dosage:9 mm x 5 mm conical suppository Administration:By suppository Result:Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number87-00-3
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Formula Weight275.4
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Molecular FormulaC16H21NO3
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Purity>98% (HPLC)
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SolubilityDMSO, Pyridine, Methanol, Ethanol, etc.
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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PF-06424439 methanes...
PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
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13-Oxyingenol dodeca...
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.
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1-Octadecanol
Octadenol is a fatty alcohol present in human and is normally incorporated into plasmalogen lipids. Sjogren-Larsson syndrome is defined by the triad of ichthyosis mental retardation and spasticity and patients accumulate fatty alcohols such as Octadenol in the plasma and cultured fibroblasts.
