Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TNF-α.

Mangostenol peroxide

Scutellarein tetramethyl ether is extracted from Siam weeds and exhibits anti-inflammatory activity through NF-κB pathway.