Lappaol F

Research use only, not for human use.

1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.

Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents. Lappaol F exhibits antitumor activity in vitro and in vivo and has strong potential to be developed as an anticancer therapeutic.Lappaol F strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with the IC(50) value of 9.5 microM.

Immunofluorescence Cell Line:HeLa cells Concentration:50 μM Incubation Time:48 h Result:Decreased the nuclear accumulation of YAP.Western Blot Analysis Cell Line:HeLa、MDA-MB-231、MCF-7 cells Concentration:50 μM Incubation Time:24, 48, 72 h Result:Increased level of p21 and p27, and reduced level of CDK2, cyclin B1, and CDK1.RT-PCR Cell Line:HeLa, MDA-MB-231, SW480 and PC3 cells Concentration:50 μM Incubation Time:12/24/36 h Result:Lowered transcriptional levels of YAP and its target genes (such as BIRC5, GLI2, c-Myc, Bcl-2, Axin2 and AREG).

Animal Model:Human colon cancer (SW480) xenografts in nude miceDosage:10 and 20 mg/kg/d Administration:i.v., 15 days Result:Inhibited tumor size by 48% (10 mg/kg/d) and 55% (20 mg/kg/d) without affecting the body weight.Induced apoptosis in tumor tissues. Up-regulated the levels of 14-3-3σin tumor tissues and down-regulated the levels of YAP.

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Others

Other Targets

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69394-17-8

714.8

C40H42O12

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years