Kuraridine

Research use only, not for human use.

Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.

Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.

Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal?IGABA?induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for?IGABA?enhancement (EC50=4.0±2.4 μM) in Xenopus?oocytes expressing GABAA?receptors composed of?α1, β2, and?γ2S?subunits.

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Others

Other Targets

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34981-25-4

438.5

C26H30O6

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (228.04 mM)

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(-20℃)

With Ice Pack

≥ 2 years