APETx2

Research use only, not for human use.

Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against acid-induced and inflammatory pain.

Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against acid-induced and inflammatory pain.

APETx2 (i.t. or i.m. application, 0.022 to 2.2 μM) resulted in a potent and complete reversal of established mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model.

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Membrane Transporter/Ion Channel

Sodium Channel

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713544-47-9

4561.06

C196H280N54O61S6

>98% (HPLC)

water:5 mg/mL

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(-20℃)

With Ice Pack

≥ 2 years