Dynorphin A

Research use only, not for human use.

Endogenous kappa receptor agonist.

Endogenous kappa receptor agonist.

Dynorphin A (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death.dynorphin A (33 μM, 4 h) elevates [Ca2+]i and causes a significant loss of neurons.dynorphin A (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe. Cell Viability Assay Cell Line:Mouse striatal neurons Concentration:10 μM Incubation Time:0, 24, 48, 72 h Result:Induced neuronal death (identified by the fragmentation and destruction of the cell body and neurites).

Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats.Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain. Animal Model:24 h water-deprived male rats Dosage:1 μg of 2 μL Administration: Intracerebroventricular injection Result:Inhibited vasopressin (VP) release 30 min upon injection. Animal Model:Male ddY mice Dosage:15, 150, 1500 pmol/5 μL per day for 4 days Administration:Intracerebroventricular injection Result: Attenuated the repeated stress-induced escape failures from the shock.

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Apoptosis

Caspase

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80448-90-4

2147.51

C99H155N31O23

>98% (HPLC)

water:0.80 mg/mL

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years