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Home - Products - Apoptosis - IL Receptor - NFAT inhibitor, Cell Permeable

NFAT inhibitor, Cell Permeable

CAS No. 592517-80-1

NFAT inhibitor, Cell Permeable( —— )

Catalog No. M30612 CAS No. 592517-80-1

NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NFAT inhibitor, Cell Permeable
  • Note
    Research use only, not for human use.
  • Brief Description
    NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.
  • Description
    NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.
  • In Vitro
    11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes.
  • In Vivo
    11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    IL Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    592517-80-1
  • Formula Weight
    3573.15
  • Molecular Formula
    C147H259N67O36S
  • Purity
    >98% (HPLC)
  • Solubility
    water:1 mg/mL
  • SMILES
    [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID:
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