Cart
sales@molnova.com
Scyliorhinin II
CAS No. 112748-19-3
Scyliorhinin II( —— )
Catalog No. M30549 CAS No. 112748-19-3
Scyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 190 | Get Quote |
|
| 10MG | 311 | Get Quote |
|
| 25MG | 624 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
Biological Information
-
Product NameScyliorhinin II
-
NoteResearch use only, not for human use.
-
Brief DescriptionScyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist.
-
DescriptionScyliorhinin II, a cyclic Tachykinin peptide, is a potent NK3 receptor agonist.(In Vitro):Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200.(In Vivo):Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice.
-
In VitroScyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200.
-
In VivoScyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice.
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetNeurokinin Receptor
-
RecptorKi: 2.5 nM (Neurokinin-3 receptor)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number112748-19-3
-
Formula Weight1851.09
-
Molecular FormulaC77H119N21O26S3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameSequence:Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11.
molnova catalog
related products
-
[Lys5,MeLeu9,Nle10]-...
Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).
-
QWF
Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
-
[Sar9,Met(O2)11]-Sub...
Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.
