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Cyclosporin D

CAS No. 63775-96-2

Cyclosporin D( —— )

Catalog No. M30364 CAS No. 63775-96-2

Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cyclosporin D
  • Note
    Research use only, not for human use.
  • Brief Description
    Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
  • Description
    Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.(In Vitro):Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.(In Vivo):Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin.
  • In Vitro
    Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
  • In Vivo
    Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    IL Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    63775-96-2
  • Formula Weight
    1216.64
  • Molecular Formula
    C63H113N11O12
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (20.55 mM)
  • SMILES
    ——
  • Chemical Name
    Sequence:cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val})

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Gschwendt M, et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun. 1988 Jan 29;150(2):545-51.
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