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IKKγ NBD Inhibitory Peptide
CAS No. 372146-18-4
IKKγ NBD Inhibitory Peptide( —— )
Catalog No. M30314 CAS No. 372146-18-4
A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameIKKγ NBD Inhibitory Peptide
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NoteResearch use only, not for human use.
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Brief DescriptionA cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
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DescriptionA cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
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In Vitro——
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In VivoAnimal Model:Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)Dosage:40 μg/4 μL Administration:Intracerebroventricular injection; 2 h before MCAO induction Result:Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number372146-18-4
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Formula Weight3693.3
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Molecular FormulaC170H259N49O42S1
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSequence:{Asp}{Arg}{Gln}{Ile}{Lys}{Ile}{Trp}{Phe}{Gln}{Asn}{Arg}{Arg}{Met}{Lys}{Trp}{Lys}{Lys}{Thr}{Ala}{Leu}{Asp}{Trp}{Ser}{Trp}{Leu}{Gln}{Thr}{Glu}
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663.
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