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DAMGO (TFA)
CAS No. 950492-85-0
DAMGO (TFA)( —— )
Catalog No. M30306 CAS No. 950492-85-0
DAMGO is a selective peptide agonist of the μ-opioid receptor .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | Get Quote |
|
| 10MG | 117 | Get Quote |
|
| 25MG | 251 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDAMGO (TFA)
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NoteResearch use only, not for human use.
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Brief DescriptionDAMGO is a selective peptide agonist of the μ-opioid receptor .
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DescriptionDAMGO is a selective peptide agonist of the μ-opioid receptor .
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In VitroDAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression.DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO.
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In VivoDAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number950492-85-0
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Formula Weight627.61
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Molecular FormulaC28H36F3N5O8
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Purity>98% (HPLC)
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SolubilityH2O : 125 mg/mL (199.17 mM; Need ultrasonic)
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SMILES——
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Chemical NameSequence:Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
FEBS Lett. 1995 Jan 2;357(1):93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.
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