Cortistatin-14( —— )

Catalog No. M30269 CAS No. 186901-48-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Cortistatin-14
Note

Research use only, not for human use.
Brief Description

Cortistatin 14 is a neuropeptide expressed in inhibitory neurons of the cerebral cortex. Depresses neuronal activity, and induces slow-wave sleep, likely through antagonism of acetylcholine. It is structurally and functionally similar to somatostatin 14. Competes with somatostatin 14 for binding of somatostatin receptors (IC50s=5, 0.09, 0.3, 0.2, and 0.3nM for receptors sst1-5, respectively).
Description

Cortistatin 14 is a neuropeptide expressed in inhibitory neurons of the cerebral cortex. Depresses neuronal activity, and induces slow-wave sleep, likely through antagonism of acetylcholine. It is structurally and functionally similar to somatostatin 14. Competes with somatostatin 14 for binding of somatostatin receptors (IC50s=5, 0.09, 0.3, 0.2, and 0.3nM for receptors sst1-5, respectively).
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

Somatostatin Receptor
Recptor

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Research Area

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Indication

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CAS Number

186901-48-4
Formula Weight

1720.03
Molecular Formula

C81H114N20O18S2
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 100 mg/mL (58.14 mM)
SMILES

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Chemical Name

Sequence:{Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)