Amyloid β-peptide (1-40) rat

Research use only, not for human use.

Rat form of the beta-Amyloid (1-40) peptide.

Rat form of the beta-Amyloid (1-40) peptide.

β-Amyloid (1-40) (rat) (1 μM; 1 h) increases 45Ca2+ influx and elevates Ca2+ in cortical synaptosomes.β-Amyloid (1-40) (rat) (3 nM) induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield and induces apoptosis.

β-Amyloid (1-40) (rat) (1.7 mg; ICV, for 7 d; swiss and C57BL/6 mice) induces the learning and memory deficits in mice. Animal Model:Swiss and C57BL/6 mice Dosage:1.7 mg Administration:Intracerebroventrical injection; for 7 days Result:Presented spatial learning and memory impairments.

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Membrane Transporter/Ion Channel

Beta Amyloid

The Amyloid β-peptide (1-40) (rat)-treated rats require longer to find the platform hidden under the water. In the visible platform test, the latency for each group is similar (20.56±11.31 s in control and 14.68±9.97 s in Amyloid β-peptide (1-40) (rat) group, p=0.304). Among these tested proteins, 6 ones are significantly up-regulated and 7 ones significantly down-regulated in Amyloid β-peptide (1-40) (rat) group comparing with the control. Tubulin β chain is significantly down-regulated in Amyloid β-peptide (1-40) (rat) group (p=0.014) when compare with control. Similar changes are also observed for ATP synthase β subunit (p=0.010) and sypsin Ib between Amyloid β-peptide (1-40) (rat) and control groups, but not significantly for sypsin Ib (p=0.295)

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144409-98-3

4233.76

C190H291N51O57S

>98% (HPLC)

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Sequence:Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

(-20℃)

With Ice Pack

≥ 2 years