Apamin TFA (24345-16-2 free base)( Apamine TFA )

Catalog No. M29921 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Apamin TFA (24345-16-2 free base)
Note

Research use only, not for human use.
Brief Description

Apamin TFA (Apamine TFA) is a toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3.
Description

Apamin TFA (Apamine TFA) is a toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3.(In Vitro):Apamin (0.5-2 μg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1.(In Vivo):Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice.
In Vitro

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In Vivo

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Synonyms

Apamine TFA
Pathway

Others
Target

Other Targets
Recptor

K+ channel
Research Area

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Indication

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CAS Number

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Formula Weight

2141.36
Molecular Formula

C81H132F3N31O26S4
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15)

Kim JY, et al. Apamin suppresses biliary fibrosis and activation of hepatic stellate cells. Int J Mol Med. 2017 May;39(5):1188-1194.

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