Epieriocalyxin A( —— )

Catalog No. M29299 CAS No. 191545-24-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Epieriocalyxin A
Note

Research use only, not for human use.
Brief Description

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
Description

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.(In Vitro):Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. EpiA induced annexin V flipping in the cell membrane and DNA fragment. We also showed that EpiA induced the generation of ROS in cells, as well as damage of the mitochondrial membrane. Western blot results showed that both JNK and ERK1/2 activation was decreased after EpiA treatment in a dose-dependent manner. EpiA increased the expression of caspase 3 and Bax and decreased Bcl2 expression.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

PERK
Recptor

ERK
Research Area

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Indication

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CAS Number

191545-24-1
Formula Weight

344.4
Molecular Formula

C20H24O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C[C@@H]1C(C)(C)C=CC([C@](CO2)1[C@@](CC[C@@](C3)([H])[C@@H](C)C4=O)([H])[C@]43C2=O)=O
Chemical Name

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