Eleutheroside B1

Research use only, not for human use.

Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities.

Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities.(In Vitro):eleutheroside B1 may affect N glycan biosynthesis, the chemokine signaling pathway, cytokine cytokine receptor interaction and, in particular, may target the POLR2A to inhibit the production of influenza virus genes.

Eeutheroside B1 (100?μg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells. RT-PCR Cell Line:Virus-infected A549 cells Concentration:100?μg/ml Incubation Time:24 hours Result:The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

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Microbiology/Virology

Influenza Virus

Influenza Virus

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16845-16-2

384.337

C17H20O10

>98% (HPLC)

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COc1cc2ccc(=O)oc2c(OC)c1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years