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MCU-i11
CAS No. 902903-59-7
MCU-i11( —— )
Catalog No. M28985 CAS No. 902903-59-7
MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 436 | In Stock |
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| 5MG | 359 | In Stock |
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| 10MG | 511 | In Stock |
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| 25MG | 847 | In Stock |
|
| 50MG | 1135 | In Stock |
|
| 100MG | 1535 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMCU-i11
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NoteResearch use only, not for human use.
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Brief DescriptionMCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
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DescriptionMCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.(In Vitro):Mitochondrial Ca2+ uptake in mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines were measured upon treatment with 10 μM compound. MCU-i11 reduced mitochondrial Ca2+ uptake in all tested cell lines, indicating the existence of a conserved mechanism. MCU-i11 had no effect on cell viability.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPI3Kδ
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Research Area——
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Indication——
Chemical Information
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CAS Number902903-59-7
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Formula Weight532.61
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Molecular FormulaC28H28N4O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCOC1=CC=C(NC(=O)CN2C3=C(C4=C(CN(CC4)C(C)=O)S3)C(=O)N(CC3=CC=CC=C3)C2=O)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Li F, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.
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