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MKC-1
CAS No. 125313-92-0
MKC-1( —— )
Catalog No. M28925 CAS No. 125313-92-0
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 129 | In Stock |
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| 5MG | 121 | In Stock |
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| 10MG | 178 | In Stock |
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| 25MG | 309 | In Stock |
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| 50MG | 436 | In Stock |
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| 100MG | 608 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMKC-1
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NoteResearch use only, not for human use.
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Brief DescriptionMKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle.
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DescriptionMKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle.
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In Vitro——
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In VivoMKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number125313-92-0
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Formula Weight400.394
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Molecular FormulaC22H16N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (124.88 mM)
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SMILESCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)[N+]([O-])=O)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hyland EE, et al. Unified Access to Pyrimidines and Quinazolines Enabled by N-N Cleaving Carbon Atom Insertion. J Am Chem Soc. 2022 Oct 26;144(42):19258-19264.
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