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TRPM4 inhibitor 8
CAS No. 1353979-43-7
TRPM4 inhibitor 8( —— )
Catalog No. M28894 CAS No. 1353979-43-7
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 56 | In Stock |
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| 25MG | 92 | In Stock |
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| 50MG | 176 | In Stock |
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| 100MG | 276 | In Stock |
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| 200MG | 416 | In Stock |
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| 500MG | 682 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTRPM4 inhibitor 8
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NoteResearch use only, not for human use.
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Brief DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
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DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
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In VitroNMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorEndothelin A receptor|Endothelin B receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1353979-43-7
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Formula Weight257.175
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Molecular FormulaC11H17BrN2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (388.85 mM)
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SMILESCCN(CCN)Cc1cccc(Br)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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MDR-652
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 are 5.05 and 93 nM respectively.
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Pyr10
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .
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9-Phenanthrol
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
