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AZ12672857
CAS No. 945396-55-4
AZ12672857( —— )
Catalog No. M28823 CAS No. 945396-55-4
AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 161 | In Stock |
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| 2MG | 89 | In Stock |
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| 5MG | 149 | In Stock |
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| 10MG | 259 | In Stock |
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| 25MG | 425 | In Stock |
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| 50MG | 647 | In Stock |
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| 100MG | 876 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZ12672857
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NoteResearch use only, not for human use.
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Brief DescriptionAZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.
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DescriptionAZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.(In Vitro):AZ12672857 shows IC50s of 240 nM and 58 nM for p-KDR in HUVEC and p-PDGFR-β in MG63 cell line. AZ12672857 moderately inhibits CYP P450 with IC50s of 5 μM for 2C9 and 3A4 and >10 μM for 1A4, 2D6 and 2C19.
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In VitroAZ12672857 shows only modest inhibition of CYP P450 (IC50=5 μM against 2C9 and 3A4, >10 μM against 1A4, 2D6 and 2C19). AZ12672857 inhibits p-KDR in HUVEC with an IC50 of 240 nM and inhibits p-PDGFR-βin MG63 cell line with an IC50 of 58 nM.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetSrc
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number945396-55-4
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Formula Weight486.57
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Molecular FormulaC26H30N8O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (51.38 mM)
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SMILESN1=CC=2C(=CC=CC2N(C3=NC(=NC=C3)NC=4C=C(C=C(C4)N5CCOCC5)N6CCOCC6)C)N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Findlay JA, Radics L. Flavipucine (3'-isovaleryl-6-methylpyridine-3-spiro-2'-oxiran-2(1H),-4(3H)-dione), an antibiotic from Aspergillus flavipes. J Chem Soc Perkin 1. 1972;16:2071-4.
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