OATD-01

Research use only, not for human use.

OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).

OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).(In Vitro):The Ki values for hCHIT1,mCHIT1, hAMCase and mAMCase are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively. These Ki values reveals good correlation with earlier established IC50 data, which are 23 nM, 28 nM, 9 nM and 7.8 nM, respectively. OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets.(In Vivo):OATD-01 given orally once daily in a range of doses between 30 and 100 mg/kg showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis.

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Animal Model:Female BALB/c mice Dosage:30 mg/kg, 100 mg/kg Administration:Oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days Result:Reduced the degree of lung fibrosis in vivo.

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Others

Other Targets

PDE3A

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2088453-21-6

390.91

C19H27ClN6O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (255.81 mM)

C[C@@H](C1)OC[C@H](Cc(cc2)ccc2Cl)N1C(CC1)CCN1c1nc(N)n[nH]1

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(-20℃)

With Ice Pack

≥ 2 years