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1-phenoxazin-10-ylethanone
CAS No. 6192-43-4
1-phenoxazin-10-ylethanone( 10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01 )
Catalog No. M28779 CAS No. 6192-43-4
1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 375 | In Stock |
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| 100MG | 533 | In Stock |
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| 200MG | 724 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name1-phenoxazin-10-ylethanone
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NoteResearch use only, not for human use.
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Brief Description1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
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Description1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
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In VitroWestern Blot Analysis Cell Line:MDA-MB-231 cell line Concentration:300 and 460 nmol/L Incubation Time:12, 24, 36 and 48 hours Result:Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.
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In VivoAnimal Model:BALB/c female nude mice with MDA-MB-231 cells injection Dosage:40 mg/kg Administration:Oral administration; 40 mg/kg, once daily for 10 days Result:Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.
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Synonyms10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01
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PathwayJAK/STAT Signaling
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TargetPim
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Recptorhistone acetyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number6192-43-4
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Formula Weight225.247
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Molecular FormulaC14H11NO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (221.99 mM)
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SMILESCC(=O)N1c2ccccc2Oc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018.
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