SGC-SMARCA-BRDVIII( —— )

Catalog No. M28766 CAS No. 1997319-84-2

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	49	In Stock
5MG	61	In Stock
10MG	103	In Stock
25MG	235	In Stock
50MG	368	In Stock
100MG	548	In Stock
200MG	Get Quote	In Stock
500MG	1190	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SGC-SMARCA-BRDVIII
Note

Research use only, not for human use.
Brief Description

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
Description

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.(In Vitro):SGC-SMARCA-BRDVIII blocks adipogenesis in 3T3-L1 murine fibroblasts.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

SCP1
Research Area

——
Indication

——

Chemical Information

CAS Number

1997319-84-2
Formula Weight

371.43
Molecular Formula

C19H25N5O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (67.31 mM)
SMILES

CC(C)(C)OC(N(CC1)CCN1c1c(N)nnc(-c(cccc2)c2O)c1)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.

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