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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - SGC-SMARCA-BRDVIII

SGC-SMARCA-BRDVIII

CAS No. 1997319-84-2

SGC-SMARCA-BRDVIII( —— )

Catalog No. M28766 CAS No. 1997319-84-2

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 49 In Stock
5MG 61 In Stock
10MG 103 In Stock
25MG 235 In Stock
50MG 368 In Stock
100MG 548 In Stock
200MG Get Quote In Stock
500MG 1190 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SGC-SMARCA-BRDVIII
  • Note
    Research use only, not for human use.
  • Brief Description
    SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
  • Description
    SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.(In Vitro):SGC-SMARCA-BRDVIII blocks adipogenesis in 3T3-L1 murine fibroblasts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    SCP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1997319-84-2
  • Formula Weight
    371.43
  • Molecular Formula
    C19H25N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (67.31 mM)
  • SMILES
    CC(C)(C)OC(N(CC1)CCN1c1c(N)nnc(-c(cccc2)c2O)c1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.
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